Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
1. What big brother is eating isn’t noodles, but loneliness.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
在被问及欧洲央行会不会采取更多行动时，朗伯德街研究(Lombard Street Research)首席欧洲经济学家达里奥·铂金斯(Dario Perkins)表示：“我不这么认为——除非全球整体经济出了问题。”
Trends and targets in antiviral phototherapy
Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.
oDesk and Elance (now in the process of merging) are freelance marketplaces, which allow you to quickly identify, engage and hire freelancers from all over the globe. Need a website developer or content writer? Don’t hire an employee; instead, work with a freelancer. At last count, there were more than 1 million freelance contractors available via these marketplaces.
Those in third-tier cities are under relatively low financial stress and human relations stress, and enjoy better social and natural environments, and infrastructure.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
"Protections that promote equality and diversity should not be conditional on someone's sexual orientation," he wrote. "For too long, too many people have had to hide that part of their identity in the workplace."
Novel biosensing methodologies for ultrasensitive detection of viruses
The London school’s MBA is ranked first in Europe, its EMBA programme, delivered jointly with Columbia Business School in the US, is ranked third and its MiM programme is in the top 10 on its first participation. The MiM ranking was the last missing piece for LBS to come first in Europe.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
May the joy of New Year be with you throughout the year.愿新年的快乐一年四季常在。
Diagnostic technologies for COVID-19: a review
Democratic frontrunner Hillary Clinton says that if she's elected president, at least half of her Cabinet will be women.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
It was the age of wisdom, it was the age of foolishness…
2017年排行榜的前几名几乎清一色都是法国商学院。校区位于里尔和尼斯的北方高等商学院(Edhec Business School)首次登上该榜单榜首。自2011年该榜单编制以来一直排名第一的巴黎高等商学院(HEC Paris)如今降至第二名。
If you want a refrigerator with a screen, might as well just stick an iPad on it. Samsung unveiled a smart refrigerator this summer that connects to wi-fi to help manage groceries and leave notes behind for family members.
What deserves to be mentioned the most is, Uber and Tesla Motors Inc did not make it to the list. "Both Uber and Tesla do innovate, but not at a sufficient level to feature in the Top 100 list of innovative organizations around the globe as measured by patent metrics of volume, success, globalization and impact. They neither have sufficiently large portfolios to qualify for inclusion with less than 100 granted inventions during 2010-2014," Stembridge said.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
In 2011, at age 15, D'Aloisio closed a seed round of funding from Li Ka-shing. A year later, Summly launched, and within a month it had attracted 500,000 users and became the number-one news app in 28 countries. The Yahoo! sale capped off a remarkable run for someone not yet out of high school. But it's not mere technological savvy that sets D'Aloisio apart. Since long before he could shave, he has been driven by an intense curiosity and a desire to make some sort of mark on the tech world. Not just to create but to build and, yes, to monetize.
在牵手其他领域的精英这一点上，谷歌并非独家。今年早些时候，英特尔（Intel）便宣布与美国时尚设计师协会（Council of Fashion Designers of America，CFDA）和奢侈品零售商Opening Ceremony合作，设计智能手镯。时尚品牌汤丽柏琦（Tory Burch）也与Fitbit携手设计了与可穿戴技术创业公司Misfit Wearables的无线运动跟踪器Shine Tracker类似的吊坠与手镯。而苹果（Apple）也发掘了各行各业的人才，包括博柏利（Burberry）前任首席执行官安吉拉o阿伦德茨（担任零售主管）、伊夫o圣o洛朗（Yves Saint Laurent）前任首席执行官保罗o丹尼佛以及耐克（Nike）的前任设计主管本o谢弗。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
vt. 把 ...
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
While the debate was supposed to be solely about foreign policy, domestic concerns were never far from the surface and the candidates took every opportunity to pivot to their stump speech attacks over the economy and tax. The same was true in the spin room afterwards where both campaign teams dispensed quickly with debate comments and moved instead to analysis of the state of the race in swing states.
Antiviral drug discovery: broad-spectrum drugs from nature
Have any franchise-leading duo reinvented themselves as spectacularly as Twilight’s Kristen Stewart and Robert Pattinson? Both have become art-house mainstays. Pattinson’s latest Good Time, keeps going his recent pattern of looking fairly unrecognisable. After he transformed himself with shaggy beard and spectacles in The Lost City of Z he now has bleach-blond hair as a bank robber who tries to pull off the perfect heist in New York City, only to get his younger brother (Ben Safdie), who suffers from a developmental disability, arrested for the crime. He tries to use the money he stole to post his brother’s bail, but complications ensue. Many complications. In addition to appearing as the younger brother, Safdie co-directs the film with his own brother Josh Safdie, and Good Time was selected to compete for the Palme d’Or at Cannes. Released November 3 in Japan, November 17 in the UK and Ireland and November 23 in Greece. (Credit: A24)
In reality, bitcoin displayed major momentum in the last year as both a technology and a movement, and looks poised to convert more skeptics in the year to come. The metrics in a range of areas prove it: the number of bitcoin-related startups and jobs has boomed; the number of accepting institutions has bloomed; and activity among developers is greater than ever.
The second chart shows the real federal funds rate (ie discounting for inflation) and the real natural rate. Again, when the federal funds rate is above its natural rate, EM crises are more common.
Influenza neuraminidase: A druggable target for natural products
Did I mention that LeBron James is a free agent this summer?
Ronaldo's monster pay-packet was the result of his eye-watering pound 38.5 million-a-year salary with Spanish giants Real Madrid and endorsement deals with the likes of Nike, watchmaker Tag Heuer and nutrition supplements group Herbalife - themselves worth pound 22 million.
The block chain has such rich potential that there is an initiative underway to create additional “side chains,” though there is controversy around that idea. “We don’t really want to mess with the main block chain right now,” says Adam Ludwin, CEO of Chain, a block chain API that makes it easier to create bitcoin applications. “It works, we don’t want to break it.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
13. “Girlhood” (Céline Sciamma)
The role of biosensors in the detection of emerging infectious diseases
Kellogg/HKUST dominated this ranking from 2009 to 2014 but lost out to Trium in 2014 and to Tsinghua University/Insead in 2015.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
If you constantly arrive late to work, or return late from breaks, it displays an attitude of complacency and carelessness. So be prompt or even a bit early to show that you are time conscious and that you do care about your job and other people’s time, as well.
According to local media, the gang, based in Nanning, the capital city of south China's Guangxi Zhuang autonomous region, was able to make up to 16,000 yuan (￡1,750) profit on every tonne of the putrid meat, by injecting it with chemicals, increasing its weight by 50 per cent.
Obama defeated Romney in a series of key swing states despite a weak economic recovery and persistent high unemployment as U.S. voters decided between two starkly different visions for the country。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The theories, yes, and also the bad statistics traditional economists use to mislead America: The worst offender, GDP is a narrow, misleading measure of America's long-term growth. And second, our obsessive focus on short-term numbers, daily stock closings, quarterly earnings, annual returns, is stunting America's long-term growth.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Buyers and Sellers
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Traditionalists include George Clooney, whose awards – best picture for Argo and best supporting Actor for Syriana – are in his library at home, and Dustin Hoffman, whose two best actor awards – the first for Kramer vs. Kramer in 1980 and the second for Rain Man nine years later, are kept in his study.
"There's a new type of wealth creation coming out," he told Reuters, adding China was having to adapt as the wider economy was "very materially slowing down".
Télécom Business School in France and Prague’s University of Economics have the most gender-balanced faculty, with exactly 50 per cent women, while Switzerland’s University of Zurich is the least balanced, with only 9 per cent. Switzerland’s IMD has the most international faculty, with 94 per cent of them from overseas, while faculty at Politecnico di Milano School of Management are all Italian.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Luckily, the singles are only half the story with Reputation. On "Dress," she's high on the rush of a new romantic thrill; on "New Year's Day," she's trying to figure out what she has after the party's over.
The report also found that nearly a quarter of people use the same password for every site they are signed up to.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Wealthy Chinese bought at least seven overseas islands in 2014.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
二月的一天，苹果(Apple)的年度股东大会进行了一个多小时，蒂姆?库克(Tim Cook)已经耐心地回答了苹果进军电视市场的计划和他如何看待谷歌眼镜(Google Glass)等各类问题。但当一位参会听众就苹果各环保项目（比如其太阳能数据中心）的盈利能力向这位首席执行官发难的时候，库克发怒了。
“An employee sent his boss a text message to say he was leaving.”
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Be prepared to save his life on numerous occasions.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
A total of 13.14 million new urban jobs were added.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
We took further steps to implement the Internet Plus action plan and the national big data strategy.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
We learned about fetal surgery’s potential to change lives.
Right now, she's focusing on her modeling career, but also hopes to branch out into acting.
Coordinated reform of medical services, medical insurance, and the medicine industry
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
这款智能产品的使用可以追溯到1800年，但在2016年它才变得“智能”。 Meet Peggy，这种洗衣挂钩能够“帮助你减轻负担”，它会在洗衣机洗好衣服的时候提醒你，并告诉你天气是否适宜晾晒衣服。该装置连接到您的手机，它会在天气变化或是需要转移晾衣服的地方时发消息提醒你。
This figure marks the highest rate of growth since 2011. As the total annual box office in China five years ago was only 10 billion yuan.
They're the top three most unaffordable housing markets in the world, according to the 13th Annual Demographia International Housing Affordability Survey: 2017, published recently.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Five programmes feature in the pre-experience ranking for the first time. The highest new entrant is Lee Kong Chian School of Business at Singapore Management University. The school came second in terms of the international mobility of its graduates, and is the first school to feature in both pre-experience and post-experience rankings.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
“We know the Netherlands and the Dutch from the Srebrenica massacre,” Mr Erdogan said, invoking the most shameful episode in modern Dutch history. “We know how rotten their character is from their massacre of 8,000 Bosnians there.”
另外，Dua Lipa想要冲击三个奖项的，最后拿到了最佳艺人奖。虽然Harry Styles可能是One Direction最时尚的成员之一，但这位具有时代标志的歌手的皇冠意外地被MTV EMA的新人和前乐队的伴侣ZAYN抢走了。
A modular microarray imaging system for highly specific COVID-19 antibody testing
金球奖的独特之处在于其同时设置电影和电视奖项。而当地时间周日的这场典礼更是前所未有地模糊了二者的界限，大大褒奖了电视领域这一年来的出众表现。现已剧终的热门电视剧集《绝命毒师》(Breaking Bad)今年首次拿下金球奖，赢得了当晚最热烈的欢呼声。该片荣获剧情类最佳系列剧集奖，片中演员布赖恩?克兰斯顿(Bryan Cranston)荣获剧情类系列剧最佳男演员。
Directing for a Mini-Series or Movie: Susanne Bier, “The Night Manager”
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The system for ensuring responsibility is taken for poverty elimination will be effectively enforced, the strictest possible evaluations and assessments of poverty alleviation will be carried out, and stern measures will be taken to address deception, falsification, and the manipulation of numbers in poverty elimination work. We must see that the results of our poverty elimination earn the approval of our people and stand the test of time.
Sounds like Taylor Swift—but, in fact, it’s her frequent competitor, Katy Perry. Largely because of her Prismatic World Tour, which is now winding down, Perry pulled in $135 million this year. She grossed more than $2 million per city over the course of 126 shows in our scoring period, and added to her total through deals with Coty, Claire’s and Covergirl.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Dachis says: The news just keeps getting worse for Mitsubishi. Low sales triggered a decision to pull out of the European market and if the levels of negative discussion are any indicator, 2013 doesn’t look to be any better.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Few years in recent decades dawned with as much of a sense of pessimism as 2014. One consistent theme in the predictions for the year was that 2014 looked eerily similar to 1914. Most pundits predicted doom and gloom, especially in east Asia. Yet, while there were many horrific events — from thedowning of flight MH17 over Ukraine, to the abduction of hundreds of schoolgirls in Nigeria and the rise of the Islamic State of Iraq and the Levant — we have avoided outright world war. Now that the year is closed, with no repetition of 1914, it may be wise to investigate why the pundits were wrong, particularly on their ideas around the potential for conflict in Asia.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Apple tops the list of World's 500 Most Influential Brands for 2016, compiled by New York-based World Brand Lab and released last Monday.
The maker of Post-it notes and Scotch tape authorized a $12 billion stock repurchase program in February, replacing its current $7.5 buyback program. 3M's (MMM, Fortune 500) move followed its announcement late last year that it intends to spend $10 billion on acquisitions and repurchase up to $22 billion of shares over the next four years.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Martial art “China Youth”(Zhao Wenzhuo and friends)
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Alfonso Cuaron won best director for the space odyssey 'Gravity,' a world-wide hit and critical favorite. The film will likely join 'American Hustle' and '12 Years a Slave' as an Oscar front-runner on Thursday, when Academy Awards nominations are announced. (The academy honors technical categories that the Globes don't.)
Anti-HIV drug repurposing against SARS-CoV-2
Meme-sharing Facebook groups have become a new college tradition, Mic reported last week, with students across the country trading inside jokes and fighting battles with rival universities via screenshot and caption.
两周后，伯恩海默等几十位著名的早期绘画大师作品交易商出席伦敦的夜间拍卖会。过去，他们通常会在这些拍卖会上购买一些作品，以备在第二年3月的荷兰马斯特里赫特欧洲美术博览会(Maastricht European Fine Art Fair)上展示。但是由于卖家们鼓励苏富比和佳士得报出更高的估价来争夺自己的拍品，所以拍卖行只针对少数富豪进行宣传，现场竞价十分冷清。
Length-scale dependence of protein hydration-shell density
"When the actual dependency ratio of pension insurance gets down to three to one, the payment cannot be lower than 17 percent. If it drops to two to one ratio, it means that everyone is going to pay 25 percent. The financial burden gets heavier when the dependency ratio gets lower. The restructuring of pension system must be finalized in two years." Yang said.
Moreover, as some of the firm’s business involves advising the government on education, such recruits’ expertise is invaluable.
周边环境：这栋房屋坐落在摩德纳岛(Modena Island)，距萨凡纳市中心大约20英里（约32公里）。据该房源的代理人说，该社区设有门禁，在栎树丛与咸水湿地之间坐落着大约20栋房屋。摩德纳岛是斯基达韦岛(Skidaway Island)的一部分，岛上有一座由佐治亚大学的海洋学研究所和一座大型州立公园。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
To put this all in a bit more perspective, the current World Cup is averaging more goals than any of the top leagues around the world averaged in 2013/14. TheNetherlands' Eredivisie was the highest scoring of the top European leagues at 3.20 and the Bundesliga was just a shade behind at 3.16. No other top European league averaged more than 2.80 last season. In theAmericas, Major League Soccer is the current pace setter at 2.89 goals per game.
Wang, the chairman of Dalian Wanda Group, took the top spot with a personal fortune of $32.1 billion, the report said, despite Ma seeing his wealth surge 41 percent from 2015.
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